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Although N -glycolylation has been responsible for an increase in immunogenicity 39 , we have recently shown that small modifications such as an azide and biotin, at the 2- N acetyl position do not have a significant effect on innate immune activation, specifically Nod2-dependent nuclear factor-κB signalling 40 , indicating a tolerance of these bioorthogonal modifications that allow for manipulation at this position to study innate immune signalling
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Fingolimod (FGD) is an antagonist of S1PRs
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