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Here, the enzyme catalyzes the reversible isomerization of l-methylmalonyl-CoA to succinyl-CoA using AdoCbl as a cofactor

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This is in contrast to functional memory CD8 T cells, which persist and very intermittently proliferate in the absence of antigen as a result of IL-7 and IL-15-mediated homeostatic proliferation, or self-tolerant T cells, which persist in antigen-free hosts, and, dependent on their history, may restore cell function in that setting