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Therefore, approximately one-third of CagriSema’s weight loss efficacy arises from an effect on energy expenditure, the blunting of metabolic adaptation, which contributes to the successful treatment of obesity

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Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185)