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Furthermore, research has also shown that α-LA and DHLA both enhance mitochondrial permeability transition and increase glucose uptake through the elevation of intracellular oxidant levels and/or by facilitating insulin receptor autophosphorylation (Bjørklund et al ., 2019)
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It would seem, however, that the combination and ratio of methylglyoxal with other components in the manuka honey counteracts the methylglyoxal component from exhibiting such toxicity, because no cytotoxicity is seen in the required testing for FDA registration of manuka honey wound-care products [44]
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