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Similarly, a study carried out in 3T3-L1 preadipocytes and C2C12 myoblasts treated with sodium arsenite up to 2 µM for 8 weeks prior inducing their differentiation into mature adipocytes and myotubes, respectively, showed that sodium arsenite reduced ISGU by decreasing GLUT4 expression, while induced oxidative stress due to reduced Sirtuin-3-dependent mitochondrial antioxidant pathways (104)
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