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In principle, the absence of catalase in peroxisomes leads to a massive increase in intraperoxisomal H 2 O 2 , which, in turn, should trigger extensive oxidation/inactivation of peroxisomal enzymes [36]
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Notably, elevated ratios of long-chain to very long-chain ceramide species in BALF correlate with inflammatory markers and lung disease severity, mechanistically linked to enhanced bacterial susceptibility and epithelial apoptosis (Zhang et al., 2008
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